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The oxymorphone in OPANA ER might cause spasm on the sphincter of Oddi. Opioids may lead to raises in serum amylase. Frequently evaluate individuals with biliary tract disease, which includes acute pancreatitis, for worsening indicators.???? ????? ???? ????? ????? ?????? ???? ???? ??????? ?????Program supportive measures need to be taken and prompt

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